The reference site for Prochlorperazine

Prochlorperazine (Compazine, Stemzine, Buccastem, Stemetil, Phenotil) is a dopamine (D2) receptor antagonist that belongs to the phenothiazine class of antipsychotic agents that are used for the antiemetic treatment of nausea and vertigo.

WHAT IS Prochlorperazine?

Prochlorperazine is a highly potent neuroleptic, which is 10-20 times more potent than chlorpromazine. This medication is in a class of drugs called phenothiazines.

Prochlorperazine is used to treat the nausea and vomiting caused by radiation therapy, cancer chemotherapy, surgery, and other conditions. It is also used to treat psychotic symptoms such as hallucinations and hostility.

It is sold under the brand names Compazine®Buccastem® and Stemetil®.

 

Brand Name(s): Compazine; Buccastem; Stemetil
CAS nº: 58-38-8
(pro klor PER a zeen)

 

Product Info

The sections below will provide you with more specific information and guidelines related to prochlorperazine and its correct use. Please read them carefully.

FDA Information

Prochlorperazine was approved by the FDA in 1956.

The branded product Compazine® was discontinued from production in 2003, but there are currently many generic versions available. A prescription is required for this medicine.

Please visit the official site of the FDA for further information.

Why is this medication prescribed?

Prochlorperazine is used to treat the nausea and vomiting caused by radiation therapy, cancer chemotherapy, surgery, and other conditions. It is also used to treat psychotic symptoms such as hallucinations, hostility and non-psychotic anxiety (nervousness).

This medicine is a highly potent neuroleptic, which is 10-20 times more potent than chlorpromazine. Prochlorperazine is in a class of drugs called phenothiazines.

Mechanism:

Prochlorperazine acts by blocking a variety of receptors in the brain, particularly dopamine receptors. Dopamine is involved in transmitting signals between brain cells. When there is an excess amount of dopamine in the brain it causes over-stimulation of dopamine receptors. These receptors normally act to modify behaviour, and over-stimulation may result in psychotic illness. Prochlorperazine blocks these receptors and stops them becoming over-stimulated, thereby helping to control psychotic illness.

Although prochlorperazine can be used in the control of psychotic conditions such as schizophrenia, it also affects receptors in an area of the brain that controls nausea and vomiting.

Other uses for this medicine

This medication has not been approved for any alternative uses other than those mentioned in the product information section.

Dosage and using this medicine

Prochlorperazine comes in the form of a tablet, extended-release (long-acting) capsule, oral liquid, and rectal suppository. This medicine is usually taken three or four times a day (tablets), or once or twice a day (extended-release capsules).

Take this medicine exactly as directed by your doctor. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you.

Each dose is best taken with a full glass (8 ounces) of water, and either with or without food or milk.

Do not crush, break, or chew the sustained-release capsules. Swallow them whole, as they are specially formulated to release slowly in your body.

Mix the concentrate with 2 to 4 ounces of water, soda, juice, milk, or semisolid food such as apple sauce or pudding.

Shake the liquid form of prochlorperazine well before measuring a dose. To ensure that you get a correct dose, measure the suspension with a special dose-measuring spoon or cup, not with a regular tablespoon. If you do not have a dose-measuring device, ask your pharmacist where you can get one.

Do not let the liquid form of prochlorperazine touch your skin or clothes.

Additionally, it is advised that you do not mix the liquid with coffee, tea, cola, grape, or apple juice.

The suppositories are for rectal use only. Ask your doctor, nurse, or pharmacist to explain how to use a suppository if you do not know how.

What special precautions should I follow?

BEFORE TAKING PROCHLORPERAZINE:

Tell your doctor if you have a bone marrow disease, glaucoma, seizures, Parkinson’s disease, kidney disease, liver disease, or an enlarged prostate. You may not be able to take this medicine, or you may require a lower dose or special monitoring during treatment if you have any of the conditions listed above.

Moreover, please inform your doctor if you are taking any of the following medicines: antacids (take antacids at least 2 hours before or 2 hours after taking a dose of prochlorperazine, otherwise they will decrease the effectiveness of your medication); alcohol; over-the-counter cough, cold, or allergy medications; sleep aids; antidepressants; muscle relaxants; barbiturates; or seizure medications. (these drugs will increase the side of effects of prochlorperazine, especially drowsiness and dizziness); blood pressure medications such as propranolol (Inderal®), methyldopa (Aldomet®), and clonidine (Catapres®) (these medicines may cause dizziness and fainting if used with prochlorperazine); anticoagulants such as warfarin (Coumadin®) (these medicines may have decreased effects, which could lead to blood clotting); and phenytoin (Dilantin®) (prochlorperazine may increase the effects of phenytoin and lead to side effects. You may need a lower dose of phenytoin).

Drugs other than those listed here may also interact with prochlorperazine. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

Additionally, it is not known whether prochlorperazine will harm an unborn baby. Do not take this medication without first talking to your doctor if you are pregnant.

Furthermore, it is not known whether this medicine will harm a nursing infant. Do not take this medication without first talking to your doctor if you are breast-feeding a baby.

If you are over 60 years of age, you may be more likely to experience side effects from prochlorperazine, and you may require a lower dose of this medication.

Use cautiously when driving, operating machinery, or performing other hazardous activities. Prochlorperazine may cause dizziness or drowsiness, so try to avoid these activities. Alcohol can also increase these symptoms and should be used in moderation.

Dizziness is also likely to occur when you rise from a sitting or lying position. Rise slowly to prevent dizziness and a possible fall.

Avoid prolonged exposure to sunlight. Prochlorperazine may increase the sensitivity of your skin to sunlight. Use a sunscreen and wear protective clothing when exposure to the sun is unavoidable.

What should I do if I forget a dose?

If you are taking prochlorperazine for nausea and vomiting, take the missed dose as soon as possible, if it is needed, and then wait at least 4 hours before taking another dose.

If you are taking prochlorperazine once a day for any other condition, take the missed dose as soon as you remember, then go back to your regular schedule the next day. If you do not remember until the next day, skip the dose you missed and take only the dose regularly scheduled for that day. It is strongly advised never to take a double dose of this medication.

On the other hand, if you are taking prochlorperazine several times a day for a condition other than nausea and vomiting, take the missed dose within 1 hour of its regular time. If more than 1 hour has passed, then skip the missed dose and take only your next regularly scheduled dose. Do not take a double dose.

What side effects can this medication cause?

If you experience any of the following serious side effects, stop taking prochlorperazine and seek emergency medical treatment:

an allergic reaction (difficulty breathing, closing of your throat, swelling of your lips, tongue, or face, or hives)
uncontrollable movements of the tongue, face, lips, arms, or legs
muscle spasms of the face or neck
severe restlessness or tremor
severe drowsiness or fainting
a rash

Other less serious side effects may be more likely to occur. Continue to take prochlorperazine and talk to your doctor if you experience:

decreased sweating
dry mouth and stuffy nose
constipation
blurred vision
mild restlessness, weakness, or tremor
difficult urination or dark urine
decreased sex drive
dizziness
increased appetite

Side effects other than those listed here may also occur, so please consult your doctor about any side effect that seems unusual or that is especially bothersome.

What storage conditions are needed for this medicine?

Store the tablets and capsules at room temperature away from moisture and heat, and store the liquid in a light-resistant container at room temperature.

Remember to throw away any medication that is outdated or no longer needed. If you have any doubts, please talk to your pharmacist about the proper disposal of your medication.

In case of an emergency/overdose

In the case of an overdose, call your local poison control center on 1-800-222-1222. However, if the victim has collapsed or is not breathing, then please call the local emergency services immediately on 911.

Symptoms of a prochlorperazine overdose include:

uncontrollable movements
agitation
seizures
severe dizziness or fainting
coma
deep sleep
irregular heartbeats
high or low body temperature

Product Images

PICTURES OF PROCHLORPERAZINE PRODUCTS

Below you will find images and specific information on the principal types of prochlorperazine that exist, including their respective brand name(s), strength, inscription codes, manufacturers and/or distributors.

The information below includes general information and guidelines for patients taking this medication and should never be used to substitute professional medical advice that can be provided by a qualified physician or family doctor.

Name: PROCHLORPERAZINE
Strength(s): 5 MG
Imprint: LOGO 3690
Manufacturer: IVAX

Name: PROCHLORPERAZINE
Strength(s): 5 MG
Imprint: M | P1
Manufacturer: MYLAN

Name: PROCHLORPERAZINE
Strength(s): 5 MG
Imprint: 93 | 9643
Manufacturer: TEVA USA

Name: COMPAZINE®
Strength(s): 5 MG
Imprint: SKF C66
Manufacturer: GLAXOSMITHKLINE

Name: PROCHLORPERAZINE
Strength(s): 10 MG
Imprint: GG 953 | 10
Manufacturer: SANDOZ

Name: PROCHLORPERAZINE
Strength(s): 10 MG
Imprint: 93 | 9652
Manufacturer: TEVA USA

Name: PROCHLORPERAZINE
Strength(s): 10 MG
Imprint: P2 | M
Manufacturer: MYLAN

Name: PROCHLORPERAZINE
Strength(s): 10 MG
Imprint: DP | 522
Manufacturer: DURAMED (BARR PHARM.)

Name: PROCHLORPERAZINE
Strength(s): 10 MG
Imprint: TL 115
Manufacturer: BRECKENRIDGE PHARM.

Name: PROCHLORPERAZINE
Strength(s): 10 MG
Imprint: LOGO 3691
Manufacturer: IVAX

Name: COMPAZINE®
Strength(s): 10 MG
Imprint: SKF C67
Manufacturer: GLAXOSMITHKLINE

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